Which syndrome is characterized by a missing gene on chromosome 15?

Prader-Willi Syndrome is characterized by an absence of paternal genetic contribution on chromosome 15, leading to a deletion or an imprinting error that results in the missing gene. This syndrome presents various symptoms like hypotonia, feeding difficulties in infancy, and later, obesity due to an insatiable appetite.

The genetic basis of Prader-Willi is associated specifically with the paternal gene expression that is disrupted, which is why it is linked to that specific chromosome. Understanding this genetic aspect is crucial in identifying the syndrome and its related health concerns. This makes it distinct and helps researchers and healthcare professionals develop appropriate interventions and support strategies for affected individuals.