Which syndrome is NOT an inherited metabolic disorder that causes intellectual disabilities?

Reye Syndrome is indeed not an inherited metabolic disorder that causes intellectual disabilities. It is primarily a condition that affects the liver and brain, often seen in children who have recently had a viral infection and subsequently received aspirin. The hallmark of Reye Syndrome is the sudden onset of severe symptoms after a viral illness, which can lead to rapid deterioration. The exact cause of Reye Syndrome is not related to inherited metabolic defects but is associated with the use of aspirin during viral illnesses in children, making it distinct from the other conditions listed.

In contrast, the other syndromes mentioned are all inherited metabolic disorders that can lead to intellectual disabilities. Adrenoleukodystrophy is a genetic disorder that affects the metabolism of very long-chain fatty acids, leading to neurological decline. Hunter Syndrome is a lysosomal storage disorder caused by a deficiency in an enzyme required to break down glycosaminoglycans, which can lead to developmental delays and cognitive impairment. Similarly, Sanfilippo Syndrome, also a lysosomal storage disorder, results from the body's inability to properly break down certain sugars, leading to progressive mental and physical decline. These conditions are linked to specific genetic mutations and often lead to intellectual disabilities, highlighting the contrast with Reye Syndrome's etiology and manifestations